Neuropeptide S Receptor
Neuropeptide S Receptor; NPSR; GPR154; Vasopressin receptor-related receptor 1; VRR1
Neuropeptide S Receptor (NPSR) is a member of the G protein-coupled receptor (GPCR) superfamily and serves as the specific receptor for neuropeptide S (NPS). Upon binding to NPS, which occurs with high affinity, NPSR activates both Gq and Gs proteins, resulting in increased intracellular calcium levels and cyclic adenosine monophosphate (cAMP) accumulation. NPSR is predominantly expressed in brain regions associated with anxiety and stress responses, including the amygdaloid complex, paraventricular hypothalamic nucleus, and hippocampus. This receptor plays significant roles in various physiological processes, including inflammation, nociception, locomotor activity, wakefulness, anxiety regulation, and food intake, and is particularly implicated in the pathogenesis of asthma[1][2].
References:
- [1]. Camilleri M, et al. Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders. Gastroenterology. 2010 Jan;138(1):98-107.e4. [Content Brief]
- [2]. Xu YL, et al. Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain. J Comp Neurol. 2007 Jan 1;500(1):84-102. [Content Brief]
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Neuropeptide S Receptor Related Products (13)
Related Products (13)
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SHA 68
0 ImagesSHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
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Neuropeptide S (human)
0 ImagesNeuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.
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ML154
0 ImagesSynonyms: NCGC84ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively.
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R06039-691
0 ImagesCat. No.: HY-186034CAS No.: 2138445-51-7R06039-691 is a neuropeptide S receptor (NPSR) agonist with an EC50 of 93 nM. R06039-691 can participate in regulating various biological functions such as arousal, stress and anxiety responses, memory processes, and food intake by activating NPSR.
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R06039-641
0 ImagesR06039-641 is a neuropeptide S receptor (NPSR) agonist with an EC50 of 169 nM. R06039-641 can participate in regulating various biological functions such as arousal, stress and anxiety responses, memory processes, and food intake by activating NPSR.
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R06039-693
0 ImagesCat. No.: HY-186032CAS No.: 2138295-88-0R06039-641 is a neuropeptide S receptor (NPSR) agonist with an EC50 of 169 nM. R06039-641 can participate in regulating various biological functions such as arousal, stress and anxiety responses, memory processes, and food intake by activating NPSR.
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NPSR1 antagonist-1
0 ImagesCat. No.: HY-175813CAS No.: 3113770-74-1NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis.
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Neuropeptide S (Mouse) TFA
0 ImagesCat. No.: HY-P1437ANeuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca2+. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.
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Buccalin
0 ImagesCat. No.: HY-P10979CAS No.: 116786-35-7Buccalin is a neuropeptide that colocalizes with small molecule cardioactive peptides in neuronal B15. When exogenously applied to the ARC neuromuscular junction, Buccalin reduces the amplitude of muscle contraction induced by motor neuron firing and acts only presynaptically. Buccalin has no effect on the rate of muscle relaxation and reduces motor neuron-induced ARC excitatory junction potentials without affecting contraction produced by direct acetylcholine action on the muscle.
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R06039-696
0 ImagesCat. No.: HY-186033CAS No.: 2138295-90-4R06039-696 is a neuropeptide S receptor (NPSR) agonist with an EC50 of 91 nM. R06039-696 can participate in regulating various biological functions such as arousal, stress and anxiety responses, memory processes, and food intake by activating NPSR.
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Neuropeptide S (human) TFA
0 ImagesCat. No.: HY-P1389ANeuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research.
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NPSR1 modulator-1
0 ImagesCat. No.: HY-180875CAS No.: 884141-05-3NPSR1 modulator-1 is a NPSR1 modulator.
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SHA 68 (Standard)
0 ImagesCat. No.: HY-108625RCAS No.: 847553-89-3SHA 68 (Standard) is the analytical standard of SHA 68. This product is intended for research and analytical applications. SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
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